Kinetic Modeling of Central Metabolic Pathway for Phenotype MicroArray Analysis
نویسندگان
چکیده
Metabolic networks link cellular phenotypes to the corresponding genotypes. Large-scale structural analysis of metabolic networks is now focusing on the mechanisms underlying robustness in structural networks. Our primary goal is to analyze the mechanisms of metabolic networks using Phenotype Microarray (PM) data. We developed a computational model of central metabolism in Escherichia coli under glucose-limited conditions to quantify NADH and ATP concentrations. We also extracted NADH concentration rates from the PM data to compare between production of our model and observation of PM data.
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تاریخ انتشار 2009